Dr Thandeka Khoza’s research focuses on employing protein biochemistry and structural biology tools to determine protein structures and mechanisms of protein-protein interaction or protein-drug interaction. Caseinolytic protease (ClcP) exploited to study the above mention research topics. This protein is of interest because it has been shown to be important in the pathogenesis of various bacterial pathogens including mycobacterium and their regulation impairs the ability of the bacteria to establish a chronic infection. Therefore detailed structural studies of ClcP will results in novel scientific approaches that can be used to diagnose and manage disease mechanisms at cellular and molecular level.
Protein expression and purification
To be added