Dr Patrick Govender

Contact Details


Building: F3

Office no: 04-031

Telephone: 031 260 7814

Fax: 031 260 7942

e-mail: govenderpt@ukzn.ac.za

 
 




Teaching

BIOC201 - Introduction to Biomolecules - To provide an insight into the molecular diversity in living systems

BIOC308 - Physiological Biochemistry - To introduce students to the physiological relatedness of various biomolecules.

BIOC316 - Immuno- and Protein Chemistry - To introduce a biochemical view of immunology and advanced aspects of protein conformation as well as to develop skills in the concomitant laboratory techniques

BIOC708 - Advanced Biochemical Core Topics 3 - To instruct students in selected advanced aspects of the control of gene expression and applications of genetic engineering technology.


Research Interests

Yeast biotechnology, flocculation, cell wall mannoproteins

Microbial biotyping

In vitro antimicrobial and anticancer drug development and evaluations



Publications


Online profiles of publications

Google Scholar :  http://scholar.google.co.za/scholar?hl=en&q=patrick+govender&btnG=&as_sdt=1%2C5&as_sdtp=


Publications list

1) Govender, P., Domingo, J. L., Bester, M. C., Pretorius, I. S. and Bauer, F. F. (2008). Controlled expression of the dominant flocculation genes FLO1, FLO5, and FLO11 in Saccharomyces cerevisiae. Applied Environmental Microbiology 74, 6041-6052.

2) Onajole, O. K., Govender, K., Govender, P., van Helden, P. D., Kruger, H. G., Maguire, G.E., Muthusamy, K., Pillay, M., Wiid, I. and Govender, T. (2009). Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents. European Journal of Medicinal Chemistry 44, 4297-4305.

3) Onajole, O. K., Govender, P., Govender, T., Maguire, G. E. M. and Kruger, H. G. (2009) Synthesis and NMR elucidation of novel pentacyclo-undecane diamine ligands. Structural Chemistry 20, 1067-1076.

4) Govender, P., Bester, M. and Bauer, F. F. (2010). FLO gene-dependent phenotypes in industrial wine yeast strains. Appl Microbiol Biotechnol 86, 931-94. Onajole, O. K., Makatini, M. M., Govender, P., Govender, T., Maguire, G. E. and Kruger, H.G. (2010). Synthesis and NMR assignment of pentacycloundecane precursors of potential pharmaceutical agents. Magn Reson Chem 48, 249-255. Muthusamy, K., Albericio, F., Arvidsson, P. I., Govender, P., Kruger, H. G., Maguire, G. E. and Govender, T. (2010). Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells. Biopolymers 94, 323-330.

5) Muthusamy, K., Arvidsson, P. I., Govender, P., Kruger, H. G., Maguire, G. E. M. and Govender, T. (2010). Design and study of peptide-based inhibitors of amylin cytotoxicity. Bioorganic Medicinal Chemistry Letters, Bioorg. Med. Chem. Lett., 20, 1360-1365

6) Onajole, O. K., Govender, P., van Helden, P. D., Kruger, H. G., Maguire, G. E., Wiid, I. and Govender, T. (2010). Synthesis and evaluation of SQ109 analogues as potential anti- tuberculosis candidates. Eur J Med Chem 45, 2075-2079.

7) Bauer, F. F., Govender, P. and Bester, M. C. (2010). Yeast flocculation and its biotechnological relevance. Appl Microbiol Biotechnol 88, 31-39.

8) Pietersen, L., Govender, P., Kruger, H., Maguire, G., Wesley-Smith, J. and Govender, T. (2010). Peptide Functionalised Gold Nanoparticles: Effect of Loading on Aggregation and Proteolysis. International Journal of Peptide Research and Therapeutics. 16, 291–295.

9) Pietersen, L. K., Govender, P., Kruger, H. G., Maguire, G. E. M. and Govender, T. (2010). Enzymatic Activation of a Peptide Functionalised Gold Nanoparticle System for Prodrug Delivery. J Nanoscience and Technology. 4, 3075-83.

10) Onajole O.K., Govender P., Govender T., Maguire G.E.M. and Kruger H.G. (2010) NMR elucidation of Novel SQ109 derivatives. Struct. Chem. 21, 1203–1209.

11) Karpoormath R., Govender P., Kruger H.G. Govender T., and Maguire G.E.M. (2010) N,N'- [(8-endo,11-endo-Dihydroxypentacyclo-[5.4.0.02,6.03,10.05,9]undecane-8,11- diyl)bis(methylenecarbonyl)] di-L-phenylalanine. Acta Cryst. E66, o2537-o2538

12) Karpoormath R., Govender P., Govender T., Kruger H.G. and Maguire G.E.M. (2010) tert- Butyl N-[(11-exo-benzyl-oxy-carbonyl-8-oxopentacyclo[5.4.0.02,6.03,10.05,9]undecane-11-endo-yloxy)carbonyl-methyl]carbamate. Acta Cryst. E66, o2607-o2608

13) Onajole, O. K., Belewa, X.V., Coovadia, Y., Govender, T., Kruger, H.G. Maguire, G.E.M., Naidu, D., Somai, B., Singh,N.and Govender, P. (2011). SQ109 analogues as potential antimicrobial candidates. Medicinal Chemistry Research. 20,1394-1401.

14) Onajole, O.K., Coovadia, Y., Govender, T., Kruger, H. G., Maguire, G. E. M., Naidu, D., Singh, N. and Govender, P. (2011). In-vitro antifungal and antibacterial activities of novel pentacycloundecane tetra-amines. Chemical Biology and Drug Design. 77, 295-297

15) Karpoormath R, Govender P, Govender T, Kruger HG, Maguire GE. (2011)Endo-11- (Dibenzyl-amino)-tetra-cyclo-[5.4.0.0.0]undecane-8-one. Acta Crystallogr Sect E o619.

16) Karpoormath, R.; Naicker, T.; Govender, T.; Kruger, H. G.; Maguire, G. E. M. (2011) Benzyl 5-hydroxy-4-oxapentacyclo[5.4.1.02,6.03,10.08,11]dodecane-3-carboxylate.Acta Crystallographica Section E-, 67, O877-U539.

17) Govender, P., Kroppenstedt, S. and Bauer, F. F. (2011). Novel wine-mediated FLO11 flocculation phenotype in commercial Saccharomyces cerevisiae wine yeast strains with modified FLO gene expression. FEMS Microbiology Letters. 317, 117-126

18) Makatini, M. M.; Petzold, K.; Shriharsha, S. N.; Soliman, M. E. S.; Honarparvar, B.; Arvidsson, P. I.; Sayed, Y.; Govender, P.; Maguire, G. E. M.; Kruger, H. G.; Govender, T. (2011).Pentacycloundecane based inhibitors of wild type C South African HIV protease. Bioorg. Med. Chem. Lett., 21, 2274-2277

19) Makatini, M. M.; Petzold, K.; Shriharsha, S. N.; Ndlovu, N.; Soliman, M. E. S.; Honarparvar, B.; Parboosing, R.; Naidoo, N.; Arvidsson, P. I.; Sayed, Y.; Govender, P.; Maguire, G. E. M.; Kruger, H. G.; Govender, T. (2011). Synthesis and Structural Studies of Pentacycloundecane-based HIV-1 PR Inhibitors: A Hybrid 2D-NMR and Docking/QM/MM/MD Approach Eur J. Med. Chem. DOI:10.1016/j.ejmech.2011.05.071

20) Karpoormath, R.; Sayed, Y.; Govender, P.; Govender, T.; Kruger, H. G; Soliman, M.; Maguire, G. E. M. Pentacycloundecane derived hydroxy acid peptides: A new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA



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