Dr Thandeka Khoza

 

Dr Thandeka Khoza’s research focuses on employing protein biochemistry and structural biology tools to determine protein structures and mechanisms of protein-protein interaction or protein-drug interaction. Caseinolytic protease (ClcP) exploited to study the above mention research topics. This protein is of interest because it has been shown to be important in the pathogenesis of various bacterial pathogens including mycobacterium and their regulation impairs the ability of the bacteria to establish a chronic infection.  Therefore detailed structural studies of ClcP will results in novel scientific approaches that can be used to diagnose and manage disease mechanisms at cellular and molecular level.


   
 Position:    Lecturer
Qualifications:    BscHons (UCT) Msc, PhD (WITS)
Research Areas:    Protein expression and purification, Protein crystallization, Protein-drug interaction
Discipline:    Biochemistry
     
Campus:    Pietermaritzurg
Telephone:    033 260 6281
Email:    KhozaT1@ukzn.ac.za
     
Recent Publications:   

Jinal N. Bhiman, Colin Anthony, Nicole A. Doria-Rose, Owen Karimanzira, Chaim A. Schramm, Thandeka Khoza, Dale Kitchin, Gordon Botha, Jason Gorman, Nigel J. Garrett, Salim S. Abdool Karim, Lawrence Shapiro, Carolyn Williamson, Peter D. Kwong, John R. Mascola, Lynn Morris and Penny L. Moore. Viral variants that initiate and 1 drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies. Nature Medicine 21, 1332–1336(2015) doi:10.1038/nm.3963 

Mufhandu HT, Gray ES, Madiga MC, Tumba N, Alexandre KB, Khoza T, Wibmer CK, Moore PL, Morris L, Khati M. UCLA1, a synthetic derivative of a gp120 RNA aptamer, inhibits entry of human immunodeficiency virus type 1 subtype C. J Virol. 2012 May; 86 (9):4989-99.


Jinal N. Bhiman, Colin Anthony, Nicole A. Doria-Rose, Owen Karimanzira, Chaim A. Schramm, Thandeka Khoza, Dale Kitchin, Gordon Botha, Jason Gorman, Nigel J. Garrett, Salim S. Abdool Karim, Lawrence Shapiro, Carolyn Williamson, Peter D. Kwong, John R. Mascola, Lynn Morris and Penny L. Moore. Viral variants that initiate and 1 drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies. Nature Medicine 21, 1332–1336(2015) doi:10.1038/nm.3963

 

Mufhandu HT, Gray ES, Madiga MC, Tumba N, Alexandre KB, Khoza T, Wibmer CK, Moore PL, Morris L, Khati M. UCLA1, a synthetic derivative of a gp120 RNA aptamer, inhibits entry of human immunodeficiency virus type 1 subtype C. J Virol. 2012 May; 86 (9):4989-99.


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