Dr Raymond Hewer


Dr Hewer is a Biochemistry Lecturer in the School of Life Sciences. His research group is involved in the field of early-stage drug discovery with a particular interest in the design and discovery of novel compounds that inhibit or otherwise modulate disease-relevant enzymes or the proteosomal degradation pathway. A broad range of techniques including molecular modelling, assay development and biochemical screening are employed in this pursuit. Work emanating from his lab, and through collaboration with local and international research groups, has been published and presented at local and international conferences. 

Position: Senior Lecturer 
Qualifications: PhD Biochemistry 
Campus: Pietermaritzburg 
Telephone: 033 260 6484 
 Email: hewerr@ukzn.ac.za 
 Research Areas: Early-stage drug discovery  
Recent Publications:

Manyeruke MH, Olomola TO, Majumder S, Abrahams S, Isaacs M, Mautsa N, Mosebi S, Mnkandhla D, Hewer R, Hoppe HC, Klein R, Kaye PT (2015). Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate ester-AZT conjugates as potential dual-action HIV-1 integrase and reverse transcriptase inhibitors. Bioorganic and Medicinal Chemistry 23 (24), 7521 - 7528.

Tandon V, Yadav P, Sur S, Abbat S, Tiwari V, Hewer R, Papathanasopoulos MA, Raja R, Banerjea AC, Verma AK, Kukreti S, Bharatam PV (2015). Design, synthesis and biological evaluation of 1,2- dihydroisoquinolones as HIV-1 integrase inhibitors. ACS Medicinal Chemistry Letters 6 (10), 1065 – 1070.

Le Noury DA, Mosebi S, Papathanasopoulos MA, Hewer R (2015). Functional roles of HIV-1 Vpu and CD74: Details and implications of the Vpu-CD74 interaction. Cellular Immunology 298, 25-32.

Traut-Johnstone T, Kanyanda S, Kriel FH, Viljoen T, Kotze PDR, van Zyl E, Coates J, Rees DJG, Meyer M, Hewer R, Williams DBG (2014). Heteroditopic P,N ligands in gold(I) complexes: Synthesis, structure and cytotoxicity. Journal of Inorganic Biochemistry, 145, 108-120.

Traut-Johnstone T, Kriel FH, Hewer R, Williams DBG (2014). 4-(3-Azaniumylpropyl)morpholin-4-ium chloride hydrogen oxalate: an unusual example of a dication with different counter-anions. Acta Cryst C, 70, 1121 – 1124.

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