Ché Pillay

Che Pillay 
Redoxin systems play central roles in DNA synthesis, antioxidant defense, signaling and metabolism. Ché Pillay's lab is determining the network properties of these systems using computational and molecular tools which have already yielded surprising insights into the dynamics and functional organization of these systems.

 Quote:   "Finding, uncovering & challenging knowledge is never giving up on science, life and society."
Position:   Lecturer
Qualifications:   PhD
Discipline:   Systems Biology
Campus:   Pietermaritzburg
 Research Areas:   Redox systems biology
 Recent Publications:   Mashamaite LN, Rohwer JM, Pillay CS. The glutaredoxin mono- and di-thiol mechanisms for deglutathionylation are functionally equivalent: implications for redox systems biology. Biosci Rep. 2015 Feb 25;35(1). pii: e00173. doi:10.1042/BSR20140157. PubMed PMID: 25514238; PubMed Central PMCID: PMC4340274.

Pillay CS, Hofmeyr JH, Mashamaite LN, Rohwer JM. From top-down to bottom-up: computational modeling approaches for cellular redoxin networks. Antioxid Redox Signal. 2013 Jun 1;18(16):2075-86. doi: 10.1089/ars.2012.4771. Epub 2013 Feb 4. Review. PubMed PMID: 23249367.

Pillay CS, Hofmeyr JH, Rohwer JM. The logic of kinetic regulation in the
thioredoxin system. BMC Syst Biol. 2011 Jan 25;5:15. doi: 10.1186/1752-0509-5-15. PubMed PMID: 21266044; PubMed Central PMCID: PMC3045320.

Pillay CS, Hofmeyr JH, Olivier BG, Snoep JL, Rohwer JM. Enzymes or redox couples? The kinetics of thioredoxin and glutaredoxin reactions in a systems biology context. Biochem J. 2009 Jan 1;417(1):269-75. doi: 10.1042/BJ20080690. PubMed PMID: 18694397


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