Dr Bubuya Masola
Bubuya-Masola 
 
Dr Masola is holder of BSc Hons degree in Biochemistry and Animal Physiology and a PhD degree in Biochemistry. His main research focus is on mechanisms by which plant derived bioactive compounds and extracts exert their anti-diabetic effects. Methods for transdermal and oral delivery of insulin are also being investigated. Dr Masola’s research interests also include protein purification and energy metabolism in the small intestine, a key tissue in nutrient absorption. Dr Masola has over 20 years of teaching experience.



Discipline:   Biochemistry
Campus:   Westville
Telephone:   031 260 7664
 Email:   masolab@ukzn.ac.za
     
Research Areas:   
1. Diabetes: 
- Mechanisms by which plant derived bioactive compounds and extracts exert their anti-diabetic effects with particular focus on the insulin signalling pathway. 
-Investigation of methods for transdermal and oral delivery of insulin.

2. Intestinal metabolism: Research is focused on enzymes of glutamine metabolism in particular phosphate-dependent glutaminase in the intestinal mucosa. The enzyme is of interest since it initiates the oxidation of glutamine, a major energy source in the small intestine which is main site of nutrient absorption.
     
 Recent Publications:  
Mukundwa A, Mukaratirwa S, Masola B (2015). Effects of oleanolic acid on the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic male Sprague-Dawley rats. Journal of Diabetes doi: 10.1111/1753-0407.12260

Oyenihi AB, Ayeleso AO, Mukwevho and Masola B (2015). Antioxidant Strategies in the Management of
Diabetic Neuropathy. BioMed Research International, Volume 2015, Article ID 515042, 15 pages
http://dx.doi.org/10.1155/2015/515042

Khathi, A., Masola, B. and Musabayane, C.T. (2013). The effects of Syzygium aromaticum derived oleanolic acid on glucose transport and glycogen synthesis in the rat small intestine. Journal of Diabetes 5:80-87. DOI:10.1111/j.1753-0407.2012.00230.x

Ngubane, P.S., Masola, B. and Musabayane C.T. (2011). The effects of Syzygium aromaticum derived oleanolic acid on glycogenic enzymes in streptozotocin induced-diabetic rats. Renal Failure 33(4): 434–439.

Masola, B. and Ngubane, N.P. (2010).The activity of phosphate-dependent glutaminase from the rat small intestine is modulated by ADP and is dependent on integrity of mitochondria. Archives of Biochemistry and Biophysics 504: 197-203.


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